The constellation of Orion has been a prominent feature in the night sky for thousands of years, and various cultures around the world have associated it with myths and legends. Orion's striking appearance in the night sky has captured the imagination of people throughout history, leading to a rich tapestry of stories and interpretations.

Greek Mythology
In Greek mythology, Orion was a mighty hunter and son of Poseidon, the god of the sea. One version of his myth involves his pursuit of the Pleiades, the seven daughters of the Titan Atlas. Orion's pursuit of the Pleiades led to his placement in the sky as a constellation. Another myth suggests that Orion was killed by a scorpion sent by Gaia, the Earth goddess, and both Orion and the scorpion were placed in the sky as constellations, Orion as the constellation of Orion and the scorpion as Scorpius.

Ancient Egyptian Mythology
In ancient Egyptian mythology, Orion was associated with the god Osiris, the god of the afterlife, death, and rebirth. Osiris was often depicted with a distinctive belt, which some scholars suggest may have been inspired by the appearance of the stars in the constellation of Orion's Belt.

Native American Mythology
Various Native American tribes have their own myths and legends associated with the constellation of Orion. For example, among the Lakota Sioux, Orion's Belt is sometimes seen as the spine of a bison, with the other stars of the constellation representing other parts of the animal.

Ancient Mesopotamian Mythology
In ancient Mesopotamian mythology, particularly in Babylonian and Sumerian cultures, there are references to a figure similar to Orion, often associated with a great hero or king. The constellation may have been seen as representing this legendary figure or as having agricultural significance, marking the seasons or guiding planting and harvesting activities.

Old Testament
In Hebrew, the constellation Orion is called "Kesil" (כְּסִיל). The word "Kesil" appears several times in the Hebrew Bible, often in poetic or metaphorical contexts. Note that while "Kesil" is often associated with the constellation Orion, the exact identification is debated among scholars, and the term may have broader astronomical or symbolic meanings in some contexts.

Amos 5:8 (New International Version):

He who made the Pleiades and Orion, who turns midnight into dawn and darkens day into night, who calls for the waters of the sea and pours them out over the face of the land — the Lord is his name.

Job 9:9 (New International Version):

He is the Maker of the Bear and Orion, the Pleiades and the constellations of the south.

Note:

The masculine noun כסיל (kesil), meaning fool or dullard (Psalm 49:10, Proverbs 1:22).

The identical masculine word כסיל (kesil), meaning either the constellations in general, or more specific the constellation Orion. Perhaps as a response to the mythology of the surrounding nations, Egypt for instance, the Hebrew word for Orion (Chesil) is exactly the same as the Hebrew word for fool.

Noun כסיל (kesil) means fool or dunce; someone who "sees" structure in uncorrelated events. This is also the word for stellar constellations in general, and more specific the constellation Orion.

Note that stellar constellations exist only in man's imagination, and are entirely equal to faces we see in clouds, conspiracies we see in unrelated events, or pseudo-scientific and religious theories we derive from otherwise explicable observations. Equating astrology's most signature stellar constellation with the word for fool clearly reveals the very nature of the means with which the Hebrews acquired and maintained their reality model.

-- Abarim Publications' Biblical Name Vault