The constellation of Orion has been a prominent feature in the night sky for thousands of years, and various cultures around the world have associated it with myths and legends. Orion's striking appearance in the night sky has captured the imagination of people throughout history, leading to a rich tapestry of stories and interpretations.

Greek Mythology
In Greek mythology, Orion was a mighty hunter and son of Poseidon, the god of the sea. One version of his myth involves his pursuit of the Pleiades, the seven daughters of the Titan Atlas. Orion's pursuit of the Pleiades led to his placement in the sky as a constellation. Another myth suggests that Orion was killed by a scorpion sent by Gaia, the Earth goddess, and both Orion and the scorpion were placed in the sky as constellations, Orion as the constellation of Orion and the scorpion as Scorpius.

Ancient Egyptian Mythology
In ancient Egyptian mythology, Orion was associated with the god Osiris, the god of the afterlife, death, and rebirth. Osiris was often depicted with a distinctive belt, which some scholars suggest may have been inspired by the appearance of the stars in the constellation of Orion's Belt.

Native American Mythology
Various Native American tribes have their own myths and legends associated with the constellation of Orion. For example, among the Lakota Sioux, Orion's Belt is sometimes seen as the spine of a bison, with the other stars of the constellation representing other parts of the animal.

Ancient Mesopotamian Mythology
In ancient Mesopotamian mythology, particularly in Babylonian and Sumerian cultures, there are references to a figure similar to Orion, often associated with a great hero or king. The constellation may have been seen as representing this legendary figure or as having agricultural significance, marking the seasons or guiding planting and harvesting activities.

Old Testament
In Hebrew, the constellation Orion is called "Kesil" (כְּסִיל). The word "Kesil" appears several times in the Hebrew Bible, often in poetic or metaphorical contexts. Note that while "Kesil" is often associated with the constellation Orion, the exact identification is debated among scholars, and the term may have broader astronomical or symbolic meanings in some contexts.

Amos 5:8 (New International Version):

He who made the Pleiades and Orion, who turns midnight into dawn and darkens day into night, who calls for the waters of the sea and pours them out over the face of the land — the Lord is his name.

Job 9:9 (New International Version):

He is the Maker of the Bear and Orion, the Pleiades and the constellations of the south.

Note:

The masculine noun כסיל (kesil), meaning fool or dullard (Psalm 49:10, Proverbs 1:22).

The identical masculine word כסיל (kesil), meaning either the constellations in general, or more specific the constellation Orion. Perhaps as a response to the mythology of the surrounding nations, Egypt for instance, the Hebrew word for Orion (Chesil) is exactly the same as the Hebrew word for fool.

Noun כסיל (kesil) means fool or dunce; someone who "sees" structure in uncorrelated events. This is also the word for stellar constellations in general, and more specific the constellation Orion.

Note that stellar constellations exist only in man's imagination, and are entirely equal to faces we see in clouds, conspiracies we see in unrelated events, or pseudo-scientific and religious theories we derive from otherwise explicable observations. Equating astrology's most signature stellar constellation with the word for fool clearly reveals the very nature of the means with which the Hebrews acquired and maintained their reality model.

-- Abarim Publications' Biblical Name Vault

The Book of Job, one of the oldest books in the Bible, contains references to several constellations and celestial phenomena. These are often cited in the context of God's power and the vastness of creation, underscoring the limitations of human understanding compared to divine wisdom. The constellations mentioned include:

1. Orion (Kesil)
   In Job 9:9 and Job 38:31, the text refers to Orion, one of the most recognizable constellations. The Hebrew word used is "Kesil", meaning "fool" or "strong one," which some interpret as a reference to the mythical figure represented by the constellation.

   "Can you loosen Orion's belt?" (Job 38:31, NIV)

   Here’s a transliteration of the Hebrew text:

   • הֲתַקְשֹׁר (Hataqshor): "Can you bind" (from the root meaning "to tie" or "bind").
   • מַעֲדַנּוֹת (Ma'adannot): "Chains" or "bonds" (referring to ties or connections).
   • כִּימָה (Kimah): "Pleiades" (a star cluster, also referred to as "Kimah" in Hebrew).
   • אֽוֹ (O): "Or" (a simple conjunction).
   • מֹשְׁכוֹת (Moshechot): "Cords" or "bands" (implying something that ties or holds).
   • כְּסִֽיל (Kesil): "Orion" (literally "Fool," traditionally understood as the constellation Orion).

2. Pleiades (Kimah)
   The Pleiades, a cluster of stars in the constellation Taurus, are mentioned alongside Orion in both Job 9:9 and Job 38:31. The Hebrew word "Kimah" refers to this star cluster, symbolizing a tightly bound group of stars.

   "Can you bind the chains of the Pleiades?" (Job 38:31, NIV)

3. The Bear (Ash)

   Often understood to refer to the constellation Ursa Major, also known as the Great Bear. The Hebrew word "Ash" is mentioned in Job 9:9. It likely refers to the brightest part of the constellation, known as the Big Dipper.

   "He is the Maker of the Bear and Orion, the Pleiades and the constellations of the south." (Job 9:9, NIV)

4. The Chambers of the South

   In Job 9:9, the phrase "the chambers of the south" is thought to refer to constellations or stars visible in the southern hemisphere. This could symbolize the broader, unseen expanse of the heavens.

   Here’s a transliteration of the Hebrew text:

   • עֹשֶׂ֣ה (Oseh): "Maker" or "He who makes."
   • עַ֭שׁ (Ash): "The Bear" (commonly understood to refer to the constellation Ursa Major).
   • כְּסִ֑יל (Kesil): "Orion" (translated as "Fool" or "Strong One" but traditionally understood as the constellation Orion).
   • וּכִימָ֥ה (Ukimah): "Pleiades" (referring to the star cluster).
   • וְחַדְרֵי־תֵֽימָן (Vechadrei-Teiman): "And the chambers of the south" (likely referring to southern constellations or stars visible in the southern sky).